# Featured Cover

**Authors:** Rai‐Hua Lai, Ren‐Hua Chung, Wan‐Yu Pai, Yi‐Chung Chen, Ka‐Hei Lam, Cheng‐Nong Lai, Jyh‐Lyh Juang

PMC · DOI: 10.1111/acel.70291 · Aging Cell · 2025-11-12

## TL;DR

This study explores how pain susceptibility and Alzheimer's risk vary based on sex and APOE genotype, mediated by the enzyme LPCAT2.

## Contribution

The study identifies a sex- and APOE genotype-dependent mechanism involving LPCAT2 in pain and Alzheimer's risk.

## Key findings

- Sex and APOE genotype influence pain susceptibility and Alzheimer's risk through lipid metabolism.
- LPCAT2 mediates these effects, linking lipid metabolism to neurological outcomes.

## Abstract

Cover legend: The cover image is based on the article Sex‐ and APOE Genotype–Dependent Pain Susceptibility and Alzheimer's Risk Mediated by the Lipid Metabolism Enzyme LPCAT2
 by Rai‐Hua Lai et al., https://doi.org/10.1111/acel.70234.

## Linked entities

- **Genes:** APOE (apolipoprotein E) [NCBI Gene 348], LPCAT2 (lysophosphatidylcholine acyltransferase 2) [NCBI Gene 54947]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12608086/full.md

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Source: https://tomesphere.com/paper/PMC12608086