# A self-assembled macrocycle with a non-closed structure for hierarchically upgraded self-assembly

## TL;DR

A new macrocycle structure was created that enables complex self-assembly into unique structures not possible through traditional methods.

## Contribution

The discovery of a non-closed macrocycle enabling hierarchical self-assembly with distinct amine building blocks.

## Key findings

- A [3 + 10] non-closed macrocycle was self-assembled using monovalent diamines.
- Hierarchical self-assembly was achieved using a dialdehyde intermediate from imine exchange.
- Structures with two types of amine building blocks were formed, unattainable via one-pot synthesis.

## Abstract

Here, a [3 + 10] non-closed macrocycle was serendipitously self-assembled, incorporating two monovalent diamines, each with an unreacted amino group. These are selectively removed via imine exchange, yielding a dialdehyde intermediate. This precursor facilitates hierarchical self-assembly into structures comprising two types of amine building blocks unattainable by one-pot synthesis.

A [3 + 10] non-closed macrocycle was self-assembled, which facilitates hierarchical self-assembly into structures with different amine building blocks unattainable by one-pot synthesis.