# Management of Treatment‐Resistant Dermatitis Herpetiformis With Tofacitinib: A Case Report

**Authors:** Armaghan Kazeminejad, Fatemeh Montazer, Mohammad Malekan

PMC · DOI: 10.1002/ccr3.71410 · Clinical Case Reports · 2025-11-12

## TL;DR

Tofacitinib successfully treated a patient with severe dermatitis herpetiformis who did not respond to standard treatments.

## Contribution

This case report demonstrates tofacitinib's potential as a treatment for treatment-resistant dermatitis herpetiformis.

## Key findings

- Tofacitinib provided effective treatment for dermatitis herpetiformis unresponsive to dapsone and gluten-free diet.
- JAK inhibition may be beneficial for refractory autoimmune skin diseases.

## Abstract

Tofacitinib may offer a safe and effective treatment alternative for patients with dermatitis herpetiformis unresponsive to dapsone and a gluten‐free diet, highlighting the potential role of JAK inhibition in refractory autoimmune skin diseases.

## Linked entities

- **Chemicals:** tofacitinib (PubChem CID 9926791), dapsone (PubChem CID 2955)
- **Diseases:** dermatitis herpetiformis (MONDO:0015614)

## Full-text entities

- **Diseases:** autoimmune skin diseases (MESH:D012871), Dermatitis Herpetiformis (MESH:D003874)
- **Chemicals:** dapsone (MESH:D003622), Tofacitinib (MESH:C479163)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12606443/full.md

## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12606443/full.md

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Source: https://tomesphere.com/paper/PMC12606443