# When Acarbose Overdose Turns Severe: Managing Hypoglycemia in an Uncommon Scenario

**Authors:** Aron Shrestha, Navin Poudel, Kshitiz Acharya, Arjun Chaudhary, Manish Acharya, Santosh Bastola, Bibek Ghimire

PMC · DOI: 10.1002/ccr3.71448 · Clinical Case Reports · 2025-11-11

## TL;DR

Acarbose overdose can cause severe hypoglycemia, requiring urgent glucose treatment and careful monitoring.

## Contribution

Highlights acarbose toxicity as a rare but critical cause of hypoglycemia, especially in psychiatric patients.

## Key findings

- Acarbose overdose can lead to life-threatening hypoglycemia.
- Rapid intravenous glucose is essential for managing severe cases.
- Patient education is crucial to prevent future overdoses.

## Abstract

Acarbose is usually safe, but overdose can trigger severe, life‐threatening hypoglycemia. In cases of unexplained low blood sugar—particularly in patients with psychiatric illness or access to hypoglycemic drugs—acarbose toxicity should be considered. Rapid intravenous glucose, careful monitoring, and patient education are vital for optimal outcomes.

## Linked entities

- **Chemicals:** Acarbose (PubChem CID 9811704)
- **Diseases:** hypoglycemia (MONDO:0004946)

## Full-text entities

- **Diseases:** psychiatric illness (MESH:D001523), toxicity (MESH:D064420), Overdose (MESH:D062787), Hypoglycemia (MESH:D007003)
- **Chemicals:** blood sugar (MESH:D001786), Acarbose (MESH:D020909), glucose (MESH:D005947)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

17 references — full list in the complete paper: https://tomesphere.com/paper/PMC12606013/full.md

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Source: https://tomesphere.com/paper/PMC12606013