# Unlocking RAS: Finding the Right Combination Is the Key **Authors:** Bjoern Papke, Channing J. Der PMC · DOI: 10.1002/ueg2.70138 · United European Gastroenterology Journal · 2025-10-21 ## Full-text entities - **Genes:** ERBB2 (erb-b2 receptor tyrosine kinase 2) [NCBI Gene 2064] {aka CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19}, PRMT1 (protein arginine methyltransferase 1) [NCBI Gene 3276] {aka ANM1, HCP1, HRMT1L2, IR1B4}, BRAF (B-Raf proto-oncogene, serine/threonine kinase) [NCBI Gene 673] {aka B-RAF1, B-raf, BRAF-1, BRAF1, NS7, RAFB1}, SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1) [NCBI Gene 6654] {aka GF1, GGF1, GINGF, HGF, NS4, SOS-1}, XYLT2 (xylosyltransferase 2) [NCBI Gene 64132] {aka PXYLT2, SOS, XT-II, XT2, xylT-II}, MDM2 (MDM2 proto-oncogene) [NCBI Gene 4193] {aka ACTFS, HDMX, LSKB, hdm2}, PTPN11 (protein tyrosine phosphatase non-receptor type 11) [NCBI Gene 5781] {aka BPTP3, CFC, JMML, METCDS, NS1, PTP-1D}, MAP2K7 (mitogen-activated protein kinase kinase 7) [NCBI Gene 5609] {aka JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7}, IGF1R (insulin like growth factor 1 receptor) [NCBI Gene 3480] {aka CD221, IGFIR, IGFR, JTK13}, NRAS (NRAS proto-oncogene, GTPase) [NCBI Gene 4893] {aka ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6}, EGFR (epidermal growth factor receptor) [NCBI Gene 1956] {aka ERBB, ERBB1, ERRP, HER1, NISBD2, NNCIS}, KRAS (KRAS proto-oncogene, GTPase) [NCBI Gene 3845] {aka 'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A} - **Diseases:** tumor (MESH:D009369), RC (MESH:D012004), CRC (MESH:D015179) - **Chemicals:** BI-2865 (-), neratinib (MESH:C487932), sotorasib (MESH:C000706028) - **Species:** Homo sapiens (human, species) [taxon 9606] - **Mutations:** G12C, V600E - **Cell lines:** SW1463 — Homo sapiens (Human), Rectal adenocarcinoma, Cancer cell line (CVCL_1718), SW837 — Homo sapiens (Human), Rectal adenocarcinoma, Cancer cell line (CVCL_1729) ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12605971/full.md ## Figures 1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12605971/full.md ## References 7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12605971/full.md --- Source: https://tomesphere.com/paper/PMC12605971