# The legacy of Bruce Ames and mitochondrial DNA mutagenicity: integrating oxidative stress, aging, and modern perspectives

**Authors:** Jennifer Dang, Jia Yu Liou, Rida Mullah, Cecilia Giulivi

PMC · DOI: 10.3389/fmolb.2025.1710944 · Frontiers in Molecular Biosciences · 2025-10-29

## Full-text entities

- **Genes:** Polg (polymerase (DNA directed), gamma) [NCBI Gene 18975] {aka PolgA}
- **Diseases:** iron deficiency anemia (MESH:D018798), iron deficiency (MESH:D000090463), hair loss (MESH:D000505), carcinogenesis (MESH:D063646), progeroid (MESH:C536423), Huntington's disease (MESH:D006816), cancer (MESH:D009369), schizophrenia (MESH:D012559), neurodegeneration (MESH:D019636), Mitochondrial (MESH:D028361), cardiovascular disease (MESH:D002318), fragile X-associated tremor/ataxia syndrome (MESH:C564105), osteoporosis (MESH:D010024), micronutrient deficiencies (MESH:D007153), carcinogenic (MESH:D011230)
- **Chemicals:** Ames (MESH:C017501), Iron (MESH:D007501), alpha-lipoic acid (MESH:D008063), nitrogen (MESH:D009584), oxygen (MESH:D010100), NAD+ (MESH:D009243), acetyl-L-carnitine (MESH:D000108), ROS (MESH:D017382), N-tert-butylhydroxylamine (MESH:C072771), ATP (MESH:D000255), heme (MESH:D006418), iron-sulfur (-), superoxide (MESH:D013481)
- **Species:** Salmonella enterica subsp. enterica serovar Typhimurium (no rank) [taxon 90371], Mus musculus (house mouse, species) [taxon 10090], Rattus norvegicus (brown rat, species) [taxon 10116], Homo sapiens (human, species) [taxon 9606]

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## References

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Source: https://tomesphere.com/paper/PMC12605215