# Analysis of influencing factors of cognitive frailty in older adults community patients based on restricted cubic spline

## TL;DR

This study identifies age, depression, and sleep quality as key factors in cognitive frailty among older adults, using a statistical model to reveal nonlinear relationships and inform targeted interventions.

## Contribution

The novel use of restricted cubic spline modeling to uncover nonlinear associations between age, depression, sleep quality, and cognitive frailty in older adults.

## Key findings

- Cognitive frailty was detected in 44.56% of surveyed older adults.
- Nonlinear associations were found between age ≥75 years, depression score ≥20, and sleep quality score ≤5 with increased cognitive frailty risk.
- The restricted cubic spline model effectively revealed these nonlinear interactions, aiding in stratified early warning and intervention strategies.

## Abstract

To investigate the influencing factors of cognitive frailty in older adults community-dwelling patients and analyze the nonlinear relationships between key variables such as age, depression scores, sleep quality, and cognitive frailty, providing a basis for accurately identifying high-risk populations and developing individualized intervention strategies.

A simple random sampling method was employed to select 16 community health service centers across 16 districts in Shanghai, conducting questionnaire surveys among 1,692 older adults patients with multiple coexisting chronic conditions. The restricted cubic spline (RCS) model was used to analyze the dose–response relationship between age, depression score (CES-D), sleep quality (PSQI), and cognitive frailty, while controlling for confounding factors such as gender, types of chronic diseases, and social engagement.

The detection rate of cognitive frailty was 44.56%. RCS analysis revealed significant nonlinear associations between age, depression score, sleep quality, and cognitive frailty. Key inflection points where the risk of cognitive frailty significantly increased were age ≥75 years, depression score ≥20 points, and sleep quality score ≤5 points. After adjusting for confounding factors, the nonlinear relationship between depression score and cognitive frailty remained significant (p = 0.043), while the associations with age and sleep quality tended to be linear.

Cognitive frailty is relatively common among community-dwelling older adults individuals, with age, depression, and sleep quality being its significant influencing factors. The restricted cubic spline model effectively reveals the nonlinear interaction characteristics of these factors, providing a scientific basis for implementing stratified early warning and precise interventions at the community level.