# A three-step, one-pot strategy to unsymmetrical 1,1-diarylalkenes

## TL;DR

This paper presents a three-step, one-pot method for making unsymmetrical 1,1-diarylalkenes using common reagents and catalysts.

## Contribution

The novelty lies in the one-pot, three-step synthesis of unsymmetrical 1,1-diarylalkenes with varied substituents.

## Key findings

- The method uses a dibromination-elimination-Suzuki Miyaura coupling sequence.
- The reaction achieves up to 70% yield with compatibility for various arylboronic acid substituents.
- Low to moderate isolated yields are typical despite high selectivity in some cases.

## Abstract

Develop a one-pot, three-step procedure for effective access to diverse unsymmetrical 1,1-diarylalkenes from readily accessible reagents, catalysts and substrates.

A three-step, one-pot procedure for the synthesis of unsymmetrical 1,1-diarylalkenes via a dibromination-elimination-Suzuki Miyaura coupling sequence has been designed and a range of reaction conditions have been screened. Although high selectivities can be achieved in some cases, the overall reaction typically proceeds in low to moderate isolated yields albeit up to 70% was observed. The reaction is compatible with a range of substituent patterns on the arylboronic acid and different styrenes.

The online version contains supplementary material available at 10.1186/s13104-025-07553-0.