# Efficient Synthesis of Amides through Thioacids Reactions with In Situ Generated Formamidine

## TL;DR

This paper presents a new method to efficiently create amides using thioacids and an in situ formamidine intermediate.

## Contribution

The novelty lies in using in situ generated formamidine with thioacids for amide synthesis under solvent-free conditions.

## Key findings

- The method allows synthesis of primary, secondary, and tertiary amides using organic thioacids.
- The protocol is scalable, solvent-free, and produces structurally diverse amides efficiently.
- Optimized conditions enable gram-scale synthesis with readily available materials.

## Abstract

A formamidine intermediate generated in situ was used
as the nitrogen
source in a reaction with thioacids to obtain amides. The synthetic
protocol described in this paper can be used in the generation of
various primary, secondary, and tertiary amides with organic thioacids
used as substrates under the optimized conditions. Notably, this protocol
uses readily available materials, is nearly solvent-free, supports
gram-scale synthesis, and yields structurally diverse amide products
with favorable efficiency.