# Copper Homeostasis is influenced by Ics3 in Saccharomyces cerevisiae

## TL;DR

This study shows that the ICS3 gene in yeast helps maintain copper balance, which is important for cell growth.

## Contribution

The study confirms ICS3's role in copper homeostasis using a new method and clarifies its specificity to copper.

## Key findings

- ICS3 positively affects copper homeostasis in yeast cells.
- ics3Δ mutants show no significant growth difference with zinc stress.
- Mating types MATa and MATα do not affect sensitivity to copper or zinc.

## Abstract

Saccharomyces cerevisiae
has several unique open reading frames that contribute to overall fitness. This study examined
ICS3
, a contributor of Cu
2+
homeostasis. Our results successfully replicate previous work by the Monteiro laboratory using a different method, confirming the positive effect of
ICS3
on maintaining copper homeostasis for cell growth. No significant difference in growth of
ics3Δ
mutants was observed for Zn
2+
, another oxidative stressor. In addition,
MATa
and
MATα
mating types did not influence sensitivity to Cu
2+
or Zn
2+
.