# Dietary Supplement With Cherry Blossom Flower and Rosa roxburghii Tratt Fruit Extract Improves Skin Aging: A Randomized, Placebo‐Controlled, Blinded Clinical Study

## TL;DR

A dietary supplement containing cherry blossom and Rosa roxburghii fruit extract improved skin hydration, elasticity, and wrinkle reduction in a clinical trial.

## Contribution

This is the first clinical study to demonstrate the synergistic anti-aging effects of sakura and RRT fruit extract on skin parameters.

## Key findings

- Skin hydration increased by 28.07% on the cheek and 25.81% on the forearm after 8 weeks of supplementation.
- Significant improvements in skin chromaticity, elasticity, and collagen index were observed compared to baseline.
- Wrinkle volume and depth decreased significantly, including forehead wrinkles and neck lines.

## Abstract

The cherry blossom flower (sakura) and
Rosa roxburghii
Tratt (RRT) fruit demonstrate well‐established antioxidant and anti‐aging properties. However, their synergistic effects on skin aging remain understudied.

This clinical study was designed to systematically evaluate the efficacy and safety of a dietary supplement containing sakura and RRT fruit extract in improving skin aging parameters.

Sixty healthy female participants aged 30–50 years were randomly allocated to receive a daily dietary supplement (150 mg sakura extract + 200 mg RRT fruit extract) or a placebo for 8 weeks. Primary outcomes‐ skin hydration, chromaticity, elasticity, collagen index, texture and scaliness, and wrinkles‐ were quantitatively assessed at baseline and week 8 using standardized instrumental methods.

After 8 weeks of intervention, the dietary supplement significantly improved skin aging parameters versus placebo. Compared to before intervention, skin hydration increased by 28.07% (cheek) and 25.81% (forearm), significant improvement of skin chromaticity and elasticity on the cheek and inner forearm were observed (p < 0.01), and the mean collagen index rose by 1.8% (cheek) or 1.27% (inner forearm). Skin texture and scaliness reduction were presented. An evident reduction in the average volume and area ratio of skin wrinkles, including forehead wrinkles, crow's feet and nasolabial folds, were observed. There are reductions in neck line number (9.51%), neck line length (10.23%) and average depth of single neck line (7.14%).

The findings indicate that the sakura and RRT fruit extract complex is a safe and effective nutraceutical for mitigating skin aging.