# Long‐Term Impact of Orthodontic Treatment on Oral Behaviours, Temporomandibular Disorder‐Related Pain, and Anxiety: An 18‐Month Prospective Study

**Authors:** Bachar Reda, Giovanna Zanon, Luca Contardo, Mohammed Nahidh, Mariam Hmeidan

PMC · DOI: 10.1111/ocr.70030 · Orthodontics & Craniofacial Research · 2025-09-12

## TL;DR

This study found that orthodontic treatment does not significantly affect oral behaviors, jaw pain, or anxiety over 18 months.

## Contribution

The study provides longitudinal evidence that orthodontic treatment does not significantly impact TMD-related pain or anxiety in university students.

## Key findings

- Orthodontic treatment had no significant effect on oral behaviors, TMD-related pain, or anxiety over 18 months.
- Non-orthodontic participants showed minor changes in behaviors and anxiety over time.
- Routine screening for these factors is not necessary for all orthodontic patients.

## Abstract

Orthodontic treatment is a common approach for correcting malocclusion but is often associated with discomfort. The aim of this study was to assess the longitudinal changes in oral behaviours, temporomandibular disorder (TMD)‐related pain and anxiety among university students undergoing orthodontic treatment compared to untreated controls.

A prospective cohort study was conducted at the University of Trieste, Italy. Participants were grouped based on the presence or absence of active orthodontic treatment and asked to complete an electronic survey comprising the Oral behaviour checklist‐21 (OBC‐21), TMD pain screener and generalised anxiety disorder‐7 (GAD‐7) at baseline (T0), after 6 months (T1), 12 months (T2) and 18 months (T3). Repeated measures ANOVA analysed within‐group changes over time, while mixed ANOVA assessed group–time interactions.

A total of 114 participants completed all follow‐ups, with 57 in each group and comparable sex distribution. In the orthodontic group, no significant changes were observed across the three measures (p > 0.05). The non‐orthodontic group showed a slight increase in OBC‐21 scores after 12 months (p = 0.034) and a decrease in GAD‐7 scores after 18 months (p = 0.048). Mixed ANOVA confirmed the absence of significant changes in the pattern of scores between the orthodontic and non‐orthodontic groups over time (p > 0.05).

Orthodontic treatment does not significantly influence oral behaviours, TMD‐related pain or anxiety over time. Routine screening for these factors in orthodontic patients is not required as a standard practice for all orthodontic patients; instead, individualised assessment should be based on clinical indications.

## Linked entities

- **Diseases:** generalized anxiety disorder (MONDO:0001942)

## Full-text entities

- **Diseases:** Anxiety (MESH:D001007), TMD (MESH:D013705), Pain (MESH:D010146), generalised anxiety disorder (MESH:D001008), malocclusion (MESH:D008310)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

43 references — full list in the complete paper: https://tomesphere.com/paper/PMC12603672/full.md

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Source: https://tomesphere.com/paper/PMC12603672