# Toward security-aware portable sequencing

**Authors:** Carson Stillman, Jonathan E. Bravo, Christina Boucher, Sara Rampazzi

PMC · DOI: 10.1038/s41467-025-66024-z · Nature Communications · 2025-11-10

## TL;DR

This paper explores how to make portable genome sequencers more secure by applying zero-trust principles.

## Contribution

The paper introduces a security framework for portable sequencing using zero-trust principles.

## Key findings

- Portable sequencers face security risks due to reliance on external systems.
- Applying zero-trust principles can mitigate these vulnerabilities.
- Security-aware workflows improve the safety of genomic data.

## Abstract

Portable genome sequencers are revolutionizing genomic research. However, their reliance on external systems introduces new vulnerabilities that threaten the security of these sequencers. By employing zero-trust principles throughout the sequencing workflow, we can enhance the security of portable sequencing technology.

## Full-text entities

- **Diseases:** Ebola (MESH:D019142), infected (MESH:D007239), DoS (MESH:D019575)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** start/stop

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12603292/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12603292/full.md

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Source: https://tomesphere.com/paper/PMC12603292