# Automated detection of radiolucent foreign body aspiration on chest CT using deep learning

**Authors:** Xiaofan Liu, Zhe Chen, Zhiyong Tang, Xun Yang, Yan Jiang, Dan Zheng, Fangfang Jiang, Fang Ni, Shuang Geng, Qiong Qian, Yan Hao, Junjie Xu, Yin Wang, Mingyuan Zhu, Xiaoqing Wang, Rob M. Ewing, Zehor Belkhatir, Guqin Zhang, Hanxiang Nie, Yi Hu, Weihua Wang, Yihua Wang

PMC · DOI: 10.1038/s41746-025-02097-w · NPJ Digital Medicine · 2025-11-10

## TL;DR

A deep learning model was developed to detect hard-to-see foreign body aspiration in chest CT scans, outperforming experts and potentially reducing missed diagnoses.

## Contribution

A novel deep learning model combining airway segmentation and classification for detecting radiolucent foreign body aspiration in chest CT scans.

## Key findings

- The model achieved over 90% accuracy and balanced recall-precision metrics across three independent cohorts.
- In a blinded evaluation, the model outperformed radiologists in recall and F1 score for detecting radiolucent FBA.
- The model has potential to reduce false negatives and support clinical decision-making in high-risk cases.

## Abstract

Radiolucent foreign body aspiration (FBA) remains diagnostically challenging due to its subtle imaging signatures on chest CT scans, often leading to delayed or missed diagnoses. We present a deep learning model integrating MedpSeg, a high-precision airway segmentation method, with a convolutional classifier to detect radiolucent FBA. The model was trained and validated across three independent cohorts, demonstrating consistent performance with accuracies above 90% and balanced recall–precision metrics. In a blinded independent evaluation cohort, the model outperformed expert radiologists in both recall (71.4% vs. 35.7%) and F1 score (74.1% vs. 52.6%), highlighting its potential to reduce missed cases (false negatives) and support clinical decision-making. This study illustrates the translational potential of artificial intelligence for addressing diagnostically complex and high-risk conditions, offering an effective tool to support radiologists in the assessment of suspected radiolucent foreign body aspiration. Code is available at https://github.com/ZheChen1999/FBA_DL.

## Full-text entities

- **Genes:** CLEC3B (C-type lectin domain family 3 member B) [NCBI Gene 7123] {aka MCDR4, TN, TNA}
- **Diseases:** lung nodules (MESH:D003074), asthma (MESH:D001249), tuberculosis (MESH:D014376), FBA (MESH:D005547), airway stenosis (MESH:D003251), bronchiectasis (MESH:D001987), atelectasis (MESH:D001261), pneumonia (MESH:D011014), pulmonary emphysema (MESH:D011656), pleural effusion (MESH:D010996), comorbidities (MESH:D004194), acute airway obstruction (MESH:D000402), COPD (MESH:D029424), cough (MESH:D003371)
- **Chemicals:** FBA (-)
- **Species:** Gallus gallus (bantam, species) [taxon 9031], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12603148/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12603148/full.md

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Source: https://tomesphere.com/paper/PMC12603148