# Effects of Paraprobiotic Limosilactobacillus fermentum HDB1098 on Hangover Improvement in Humans: A Randomized Double-Blind Placebo-Controlled Crossover Clinical Trial

## TL;DR

This study shows that a paraprobiotic called HDB1098 can reduce hangover symptoms and lower alcohol and acetaldehyde levels in the blood.

## Contribution

The study demonstrates the efficacy of Limosilactobacillus fermentum HDB1098 in alleviating hangover symptoms through a clinical trial.

## Key findings

- HDB1098 significantly reduced serum alcohol and acetaldehyde levels compared to a placebo.
- Participants taking HDB1098 reported significantly lower hangover symptom scores.
- The paraprobiotic improved several indicators of hangover severity.

## Abstract

Hangover refers to various mental and physical side effects following alcohol consumption. This study investigated the efficacy of paraprobiotic Limosilactobacillus fermentum HDB1098 (MB-LFH1098, Pharmavio ALC) on improving hangover symptoms and was designed as a randomized double-blind crossover placebo-controlled clinical trial conducted with 28 participants. Participants consumed 42.8% whiskey with equivalent to 90 g of alcohol and serum alcohol and acetaldehyde levels were measured at 0, 0.25, 0.5, 1, 2, 4, 6, and 15 h after alcohol consumption. Both serum alcohol (p < 0.01) and acetaldehyde (p < 0.05) levels over time, AUC, Cmax, and Tmax for serum acetaldehyde level were significantly lower (p < 0.05) in the HDB1098 group compared to the placebo group. Furthermore, the total scores of AHS and AHSS were significantly lower (p < 0.0001) in the HDB1098 group than the placebo group, with improvement of several indicators in each questionnaire. These findings indicate that HDB1098 administration can effectively contribute to relief of hangover symptoms.