# Applications of Olefin Metathesis in the Synthesis of Fluorinated Substrates and Design of Fluorinated Catalysts

## TL;DR

This paper reviews recent advances in using olefin metathesis to synthesize fluorinated compounds, which are important in drug discovery.

## Contribution

The paper provides an updated analysis of metathesis applications in fluorinated compound synthesis since a major 2015 review.

## Key findings

- Olefin metathesis is a powerful tool for creating fluorinated organic compounds.
- Recent advances include improved methods for fluorinated substrate synthesis.
- New fluorinated catalysts have been designed for more efficient metathesis reactions.

## Abstract

As a result of the high pharmaceutical relevance of organofluorine compounds in drug discovery, the synthetic approach towards this class of derivatives has generated increasing interest in organic chemistry over the past decade. Metathesis, with the manipulation of the C = C double bonds, is considered to be a powerful tool in preparative organic chemistry to access various sophisticated and densely functionalized scaffolds with olefin bonds in their structure. The current paper is intended to describe, investigate, and analyze the most impactful advances and applications of metathesis with organofluorine molecular entities achieved since the outstanding review by Fustero, Haufe and others (Chem. Rev. 2015, 115, 871 − 930, dx.doi.org/10.1021/cr500182a) published a decade ago.