# Innate immunity in chemotherapy-induced peripheral neuropathy: recent advances

## TL;DR

This review explores how the body's innate immune system contributes to chemotherapy-induced nerve damage and pain.

## Contribution

The paper provides a comprehensive overview of the innate immune system's role in CIPN, highlighting recent advances.

## Key findings

- The innate immune system plays a significant role in the development of CIPN.
- Innate immune cells and molecules are involved in the pathogenesis of CIPN.
- Modulation of the innate immune response may offer new therapeutic strategies for CIPN.

## Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect in patients undergoing chemotherapy. Many commonly used chemotherapeutic agents simultaneously induce neurotoxicity and modulate the immune system. Emerging evidence highlights a critical role of the innate immune system in the development of various neuropathic pain conditions. As a natural immune defense mechanism formed during phylogenetic evolution, innate immunity elicits a robust response during CIPN pathogenesis. This review summarizes the roles of the innate immune system—including the skin barrier, innate immune cells, and innate immune molecules—in the context of CIPN.