# Colonic metastasis of a huge soft uterine leiomyoma in a postmenopausal woman: a case report

**Authors:** JianXin Tang, RuiBo Xu, XiaoYu Xi, Ying Liu, ZengFang Hao, JieXian Du, XiaoLi Du

PMC · DOI: 10.3389/fonc.2025.1660443 · Frontiers in Oncology · 2025-10-28

## TL;DR

A rare case of a benign uterine tumor metastasizing to the colon in a postmenopausal woman is reported, highlighting its unusual growth pattern.

## Contribution

This case report documents a rare instance of colonic metastasis from a benign uterine leiomyoma.

## Key findings

- A 59-year-old woman had a large uterine leiomyoma that metastasized to the sigmoid colon.
- The tumor exhibited an invasive growth pattern similar to malignant tumors.
- Immunohistochemical analysis confirmed the benign nature of the tumor despite its aggressive features.

## Abstract

.Uterine leiomyomas are the most common benign tumors of the female reproductive system, arising from the overgrowth of smooth muscle tissue within the uterus. Typically, they present as solid, spherical masses that are firmer than the surrounding uterine muscle layer. Onset generally occurs between the ages of 30 and 50, with these tumors often located in the uterine body or cervix. Some women may experience gradual tumor enlargement, accompanied by symptoms such as vaginal bleeding, lower abdominal pain, frequent urination, and constipation. In such instances, surgical treatment should be considered the first choice.

In this case, A 59-year-old woman presented with a large, soft, and irregularly shaped uterine leiomyoma, formed by the fusion of hundreds of smaller fibroids, which had metastasized to the sigmoid colon.Immunohistochemical analysis further demonstrated that benign uterine leiomyomas may present with morphological features, consistency, and an invasive growth pattern akin to malignant tumors.

Uterine leiomyomas are benign tumors that rarely metastasize; however, case reports have documented instances of distant metastasis.

The purpose of this study is to report a case of a uterine leiomyoma with intestinal metastasis, analyze its rare characteristics and invasive growth pattern, and enhance the understanding of this tumor.

## Linked entities

- **Diseases:** uterine leiomyoma (MONDO:0007886)

## Full-text entities

- **Diseases:** Uterine leiomyomas (OMIM:150699), bleeding (MESH:D006470), benign tumors (MESH:D009369), metastasis (MESH:D009362), abdominal pain (MESH:D015746), constipation (MESH:D003248)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

17 references — full list in the complete paper: https://tomesphere.com/paper/PMC12602207/full.md

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Source: https://tomesphere.com/paper/PMC12602207