# The promise and perils of humanized mice: workshop report from the 29th scientific conference of the society on NeuroImmune pharmacology (SNIP)

## TL;DR

This workshop report discusses the use of humanized mice in HIV/AIDS research, highlighting their potential and challenges.

## Contribution

The paper provides a detailed summary of a workshop on humanized mouse models for HIV/AIDS research.

## Key findings

- The workshop covered the generation and care of humanized mouse models.
- Presentations focused on HIV evolution, latency, and elite control in these models.
- Shared resources were emphasized as a way to advance humanized mice research.

## Abstract

On June 8, 2025, the 29th Scientific Conference of the Society on NeuroImmune Pharmacology (SNIP) hosted a workshop on the Creation, Care, and Translation of Humanized Mouse for HIV/AIDS Research. The workshop was convened by the society officers Drs. Howard E. Gendelman and Santhi Gorantla. A series of four presentations provided details about the generation, care and use of humanized mouse models. The presentation titles and presenters were: (i) “Next-Generation Humanized Mouse Models of HIV/AIDS Research” by Dr. Angela Wahl; (ii) “Advancing Humanized Mice Research Through Shared Resources” by Dr. Jennifer Koblinski; (iii) “NeuroHIV Humanized Mouse Models” by Dr. Santhi Gorantla; and (iv) “Studies on HIV Evolution, Latency, and Elite Control in Humanized Mice” by Dr. Ramesh Akkina. The presentations were followed by a discussion with workshop participants led by Dr. Paul W. Denton. Presentation summaries are provided in this report and are followed by questions offered by workshop participants alongside panel responses.