# A Rare Case of Penile Cutaneous Horn With Underlying Well-Differentiated Squamous Cell Carcinoma: A Case Report

**Authors:** Varsha Raja Ayyanar, Vasudeo Ridhorkar

PMC · DOI: 10.7759/cureus.96505 · Cureus · 2025-11-10

## TL;DR

This case report describes a rare instance of a penile cutaneous horn linked to squamous cell carcinoma in a 55-year-old man.

## Contribution

The novelty lies in the rare association of a penile cutaneous horn with an underlying well-differentiated squamous cell carcinoma.

## Key findings

- A penile cutaneous horn was found to be associated with a well-differentiated squamous cell carcinoma.
- Histopathological analysis confirmed the presence of malignancy in the patient's penile lesion.

## Abstract

A hard, conical growth that protrudes from the skin's surface and resembles a small horn is known as a cutaneous horn or cornu cutaneum. The horn consists of compact keratin fibers. Cutaneous horns commonly develop on photo-exposed regions and, in exceedingly rare cases, the penis. Although cutaneous horns can develop on healthy skin, they are more widely associated with preexisting skin conditions. We report a rare case of a penile cutaneous horn in a 55-year-old man presenting with pain and a growth on his penis that had persisted for a year. The patient underwent a penile glansectomy under spinal anesthesia. Histopathology revealed a well-differentiated squamous cell carcinoma, indicating malignancy.

## Linked entities

- **Diseases:** squamous cell carcinoma (MONDO:0005096)

## Full-text entities

- **Diseases:** Well-Differentiated Squamous Cell Carcinoma (MESH:D002294), Cutaneous Horn (MESH:D009261), pain (MESH:D010146), malignancy (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12600001/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12600001/full.md

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Source: https://tomesphere.com/paper/PMC12600001