# Syphilitic Aortitis Incidentally Detected by Fluorine-18 Fluorodeoxyglucose (18F-FDG) PET/CT

**Authors:** Kazunori Seo, Hiroshi Oiwa

PMC · DOI: 10.7759/cureus.94353 · Cureus · 2025-10-11

## TL;DR

A rare case of syphilitic aortitis was discovered using a PET/CT scan, highlighting its potential for early detection.

## Contribution

This case demonstrates how 18F-FDG PET/CT can detect syphilitic aortitis before symptoms appear.

## Key findings

- Syphilitic aortitis was detected incidentally using 18F-FDG PET/CT imaging.
- Early detection via PET/CT may allow timely intervention and prevent severe complications.

## Abstract

Syphilis shows a variety of symptoms at various stages; it is a sexually transmitted infection caused by Treponema pallidum. Syphilitic aortitis is a recognized complication of tertiary syphilis that may progress to aortic aneurysm formation. Because this condition can be fatal, early diagnosis is crucial to optimize patient outcomes. We describe a rare case of syphilitic aortitis incidentally detected by Fluorine-18 fluorodeoxyglucose (18F-FDG) PET/CT. Utilization of 18F-FDG PET/CT imaging can facilitate the identification of syphilitic aortitis during its subclinical phase, thereby enabling timely intervention and potentially averting severe or fatal complications.

## Linked entities

- **Diseases:** syphilis (MONDO:0005976), syphilitic aortitis (MONDO:0006992), aortic aneurysm (MONDO:0005160)
- **Species:** Treponema pallidum (taxon 160)

## Full-text entities

- **Diseases:** Syphilis (MESH:D013587), infection (MESH:D007239), Syphilitic Aortitis (MESH:D013589), aortic aneurysm (MESH:D001014)
- **Chemicals:** 18F-FDG (MESH:D019788)
- **Species:** Homo sapiens (human, species) [taxon 9606], Treponema pallidum (species) [taxon 160]

## Full text

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## Figures

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## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12599849/full.md

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Source: https://tomesphere.com/paper/PMC12599849