# Advancing Cancer Biology: Highlights from the 2025 FASEB SRC on Cellular Plasticity in Cancer

## TL;DR

This conference brought together experts to discuss how cancer cells change and adapt, with the goal of improving cancer treatments.

## Contribution

The conference highlighted new insights into cancer cell plasticity and potential therapeutic strategies.

## Key findings

- Discussed oncofetal reprogramming and its role in tumor development.
- Explored mechanisms of metabolic reprogramming in tumor progression.
- Examined cancer stem cell programs and immune evasion strategies.

## Abstract

The inaugural FASEB Science Research Conference (SRC) on Cellular Plasticity in Cancer was held in May 2025 in Hong Kong SAR, China. This event brought together leading experts to discuss cutting-edge research centered on cancer cell plasticity. The conference featured comprehensive presentations covering a broad spectrum of topics, including oncofetal reprogramming in tumor development and progression, mechanisms regulating cancer cell plasticity, metabolic reprogramming and its role in tumor progression, cancer cell plasticity during metastasis, cancer stem cell programs within the tumor microenvironment, tumor plasticity and immune evasion, as well as innovative therapeutic strategies aimed at targeting stem cell-like states, modulating cancer cell states, and effectively controlling disease progression. It is anticipated that the insights gained from this meeting will catalyze further advancements in cancer biology and therapy.