# An Fe(II)-catalyzed synthesis of spiro[indoline-3,2'-pyrrolidine] derivatives

## TL;DR

A new method was developed to synthesize spiro[indoline-3,2'-pyrrolidine] derivatives using a two-step process with Fe(II) catalysis.

## Contribution

The novel contribution is an Fe(II)-catalyzed spirocyclization method for synthesizing spiro[indoline-3,2'-pyrrolidine] derivatives.

## Key findings

- The synthetic method shows a broad substrate scope and good functional group tolerance.
- The synthesized spirocyclic compounds did not exhibit significant antimicrobial activity.

## Abstract

A synthetic strategy for the preparation of spiro[indoline-3,2'-pyrrolidine] derivatives has been developed, featuring a two-step sequence consisting of the reaction of 2-arylindoles with α,β-unsaturated ketones, followed by Fe(II)-catalyzed spirocyclization of readily accessible oxime acetates. The method exhibits a broad substrate scope and good functional group tolerance. The synthesized spirocyclic compounds showed no significant antimicrobial activity.