# Ex-situ generation of gaseous nitriles in two-chamber glassware for facile haloacetimidate synthesis

## TL;DR

A new two-chamber method safely generates toxic gaseous reagents for making fluorinated haloacetimidates under mild conditions.

## Contribution

A safe and practical two-chamber setup for ex-situ generation of gaseous nitriles for haloacetimidate synthesis is introduced.

## Key findings

- The two-chamber method allows safe generation of fluoroacetonitriles.
- The method enables synthesis of new haloacetimidates under mild conditions.
- The approach is easy to setup and control.

## Abstract

The synthesis of fluorinated haloacetimidates relies on the access to the corresponding fluoroacetonitriles, which are toxic gaseous molecules difficult to store and handle. In this work we develop a safe two-chamber method for the ex-situ generation of these reagents in one chamber and their subsequent reaction with O-nucleophiles in the second chamber. The method is easy to setup, control and gives access to new haloacetimidates under mild conditions, similar to the ones used for the synthesis of the more commonly used trichloroacetimidates.