# Synthetic study toward vibralactone

## TL;DR

This paper describes a new synthetic approach to create vibralactone, a compound that inhibits pancreatic lipase.

## Contribution

A novel method for synthesizing an all-carbon quaternary center in vibralactone is introduced.

## Key findings

- The all-carbon quaternary center in vibralactone was successfully synthesized.
- Intramolecular alkylidene carbene C–H insertion was used to form the cyclopentene ring.

## Abstract

A synthetic study toward vibralactone, a potent inhibitor of pancreatic lipase, is reported. The synthesis of the challenging all-carbon quaternary center within the cyclopentene ring was achieved through intramolecular alkylidene carbene C–H insertion.