# Primary Dural Diffuse Large B-Cell Lymphoma: A Case Report

**Authors:** Yoshiaki Takamura, Takatoshi Fujimoto

PMC · DOI: 10.31662/jmaj.2025-0198 · JMA Journal · 2025-09-05

## TL;DR

A rare case of primary dural diffuse large B-cell lymphoma in a 78-year-old woman is reported, diagnosed after imaging and surgery.

## Contribution

This case report presents a rare instance of primary dural lymphoma classified as diffuse large B-cell lymphoma rather than the typical mucosa-associated lymphoid tissue type.

## Key findings

- The patient presented with status epilepticus and an extra-axial mass lesion on MRI.
- Histopathological and immunohistochemical analysis confirmed diffuse large B-cell lymphoma.
- The case highlights the unusual clinical and pathological features of primary dural lymphoma.

## Abstract

Primary dural lymphoma is a rare subtype of primary central nervous system lymphoma that arises from the dura mater. The majority of primary dural lymphomas are histologically mucosa-associated lymphoid tissue lymphoma. We present a rare case of a 78-year-old woman with primary dural lymphoma diagnosed as diffuse large B-cell lymphoma. She was admitted with status epilepticus. Magnetic resonance imaging showed an extra-axial mass lesion in the right parieto-occipital region, which enhanced homogeneously with contrast medium. To obtain a histopathological diagnosis, resection of the lesion involving the dura mater was performed. Based on histopathological and immunohistochemical examinations, the patient was diagnosed with diffuse large B-cell lymphoma. We summarize the clinical characteristics of this unusual disease.

## Linked entities

- **Diseases:** diffuse large B-cell lymphoma (MONDO:0018905)

## Full-text entities

- **Diseases:** Primary dural lymphoma (MESH:D008223), Diffuse Large B-Cell Lymphoma (MESH:D016403), mucosa-associated lymphoid tissue lymphoma (MESH:D018442), status epilepticus (MESH:D013226)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12598186/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12598186/full.md

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Source: https://tomesphere.com/paper/PMC12598186