# Drug repurposing of natural depsipeptide from Eleftheria terrae isolated via iChip for anti-breast cancer therapy

**Authors:** Nuriyatul Fhatonah, Tedi Rustandi, Usama Ramadan Abdelmohsen, La Ode Akbar Rasydy, Ma’sum, Yomna Elghanam, Imran Pashar, Nordin, Ahmed Mahal, Akhmad Riski

PMC · DOI: 10.3389/fphar.2025.1694322 · Frontiers in Pharmacology · 2025-10-27

## TL;DR

This paper explores using a natural depsipeptide from Eleftheria terrae, isolated via iChip, for repurposing as a drug to treat breast cancer.

## Contribution

The novel contribution is the isolation and potential repurposing of a depsipeptide from Eleftheria terrae for anti-breast cancer therapy.

## Key findings

- A depsipeptide from Eleftheria terrae was isolated using the iChip method.
- The compound shows potential for repurposing as an anti-breast cancer drug.

## Abstract

Diagram showing a drug development process using AI. Left panel depicts molecular structures of teixobactin and clovibactin. Middle section illustrates pharmacochemistry, ADMET pharmacokinetics, and pharmacodynamics targeting with clinical trial simulation using AI. Right section covers side effects, prognosis, and diagnosis using multimodal electronic health records.

## Linked entities

- **Chemicals:** teixobactin (PubChem CID 86341926), clovibactin (PubChem CID 142449498)
- **Diseases:** breast cancer (MONDO:0004989)
- **Species:** Eleftheria terrae (taxon 1597781)

## Full-text entities

- **Diseases:** breast cancer (MESH:D001943)
- **Chemicals:** clovibactin (-), teixobactin (MESH:C000594838), depsipeptide (MESH:D047630)
- **Species:** Eleftheria terrae (species) [taxon 1597781]

## Full text

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## Figures

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## References

86 references — full list in the complete paper: https://tomesphere.com/paper/PMC12598032/full.md

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Source: https://tomesphere.com/paper/PMC12598032