# Effectiveness of medical ozone injections into the intervertebral disc on relieving lumbosacral pain–a systematic review and meta-analysis

## TL;DR

Medical ozone injections into the intervertebral disc can significantly reduce lower back and sacral pain in the short term compared to other treatments.

## Contribution

This study provides a systematic review and meta-analysis confirming the short-term efficacy of ozone injections for lumbosacral pain.

## Key findings

- Ozone injections reduced pain scores (VAS) by 2.13 points compared to other treatments.
- Functional improvement (ODI) was also significantly better with ozone injections.
- The treatment showed superior short-term efficacy but requires long-term evaluation.

## Abstract

To investigate the clinical efficacy of medical ozone injections into the intervertebral disc on relieving lumbosacral pain. through a systematic review and meta-analysis.

A comprehensive literature search was conducted in PubMed, Cochrane Library, and Web of Science for English-language randomized controlled trials (RCTs) published between January 2010 and January 2025. The study was registered in the PROSPERO International Prospective Register of Systematic Reviews (CRD42023417837). Primary clinical outcomes included pain reduction assessed by Visual Analog Scale (VAS) scores and functional improvement assessed by the Oswestry Disability Index (ODI). Statistical analyses were performed using Review Manager 5.4.

Eight RCTs involving 1,744 patients were included. Among them, 903 people received medical ozone injections into the intervertebral discs, while 841 people received other forms of treatment. Meta-analysis showed that medical ozone injections significantly reduced VAS scores (mean difference = −2.13, 95% CI: −2.33 to −1.93, p < 0.05) and improved ODI scores (mean difference = −0.79, 95% CI: −0.95 to −0.63, p < 0.05), indicating superior short-term efficacy compared to conventional treatments.

Ozone injection into the intervertebral discs is an effective non-invasive treatment method, which can effectively relieve pain in the lumbar and sacral regions, especially showing significant effects in the short term. However, Further long-term studies are warranted to evaluate the durability of clinical benefits.

https://www.crd.york.ac.uk/PROSPERO/view/CRD42023417837, PROSPERO CRD42023417837.