# Chronic diseases and depressive symptoms in China: a psychosocial mechanism perspective

**Authors:** Qingqing Xu, Ruizhe Shang, Xia Jiang

PMC · DOI: 10.3389/fpubh.2025.1696199 · Frontiers in Public Health · 2025-10-27

## TL;DR

This study explores how chronic diseases in China increase the risk of depression through psychosocial factors like income satisfaction and job safety.

## Contribution

The study identifies three psychosocial pathways linking chronic diseases to depression and highlights demographic differences in these effects.

## Key findings

- Chronic diseases significantly increase the risk of depressive symptoms (OR = 1.671, p < 0.01).
- Income satisfaction, job safety satisfaction, and social cognitive capital partially mediate the relationship between chronic illness and depression.
- The impact of chronic illness on depression is stronger for males, those with weak social support, and non-internet users.

## Abstract

Although the co-morbidity of chronic diseases and depression has been widely documented, its psychosocial mechanisms have not been systematically explored. This study analyzed the impact of chronic disease on depression, while emphasizing the mediating roles that income satisfaction, job safety satisfaction, and social cognitive capital play in the psychosocial mechanism.

Using the 2022 China Family Tracking Survey (CFPS) data, this study conducted a baseline regression using an ordered logit model, and explored the pathways of chronic illnesses on depressive symptoms through mechanism tests and heterogeneity analyses (n = 7,896).

Chronic conditions are associated with a considerable increase in the risk of depressive symptoms (OR = 1.671, p < 0.01). Mechanistic analyses showed that income satisfaction, job safety satisfaction and social cognitive capital all played partial mediating roles. Heterogeneity analyses indicated that the impact of chronic illness on depression was stronger among males, individuals with less robust social support, and non-users of the Internet.

This research reveals that chronic illness constitutes a notable risk factor for depression and underscores its indirect impacts on mental health through three psychosocial pathways: financial strain, job safety, and insufficient interpersonal trust. The results emphasize the importance of integrating socioeconomic support, workplace improvement and digital health resources in chronic disease management to mitigate the risk of depression.

## Linked entities

- **Diseases:** depression (MONDO:0002050)
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Diseases:** Chronic diseases (MESH:D002908), depression (MESH:D003866)

## Full text

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## Figures

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## References

56 references — full list in the complete paper: https://tomesphere.com/paper/PMC12597915/full.md

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Source: https://tomesphere.com/paper/PMC12597915