# Comparison of readmission outcomes and complications between leadless and traditional transvenous pacemakers in older adults: a nationwide readmission analysis of 49852 admission events

## TL;DR

Leadless pacemakers are linked to fewer device-related complications compared to traditional pacemakers in older adults, based on nationwide data.

## Contribution

This study provides real-world evidence comparing leadless and traditional pacemakers in older adults using a large national database.

## Key findings

- Leadless pacemakers had significantly fewer device-related complications compared to traditional pacemakers.
- Thirty-day readmission rates were similar between the two types of pacemakers.
- Mortality and hospital stay duration were not significantly different between groups.

## Abstract

While transvenous pacemakers (TV-VVI) are standard for bradyarrhythmia, lead- and pocket-related complications remain concerns. Leadless pacemakers (LPMs) may reduce these risks. However, direct comparisons between LPMs and single-chamber TV pacemakers are limited. This study aimed to compare clinically meaningful outcomes between LPM and TV-VVI using real-world data.

Using the National Readmissions Database (NRD), we analysed demographics, readmission rates, and 30-day outcomes of patients aged ≥65 years who underwent LPM or TV-VVI implantation between 2016 and 2022. Admissions were identified via ICD-10 codes. Outcomes were assessed in the propensity score-matched population (10 594 patients per group) through multivariable logistic regression after 1:1 high-dimensional propensity score matching (caliper 0.1 SD) to adjust for confounding. Among 49 852 patients, 44.8% received LPM. Median age was 84 vs. 81 years in TV-VVI and LPM groups; 46.2% were female. TV-VVI patients had significantly higher rates of device-related complications [adjusted OR (aOR): 0.45, 95% CI (0.30–0.65), P < 0.001], device revision or replacement [aOR: 0.20, 95% CI (0.11–0.36), P < 0.001], implant-related complications [aOR: 0.58, 95% CI (0.34–0.97), P = 0.040]. Crude rates of arteriovenous fistula, pseudoaneurysm, and pericardial complications were higher in LPM, but adjusted differences were non-significant. Thirty-day readmission rates were similar between LPM and TV-VVI groups at 15.5% and 15.9%, respectively. Mortality and prolonged length of hospital stay also showed no significant differences.

Nationally representative data indicate that LPM implantation is associated with fewer device-related complications compared to TV-VVI, though further studies are needed to evaluate long-term outcomes.

Graphical Abstract