# Envisioning a Multidisciplinary HBV Cure Research Agenda

## TL;DR

This paper reviews the need for a multidisciplinary approach to developing a hepatitis B cure, considering social, ethical, and practical challenges.

## Contribution

The paper emphasizes the integration of socio-behavioral and translational sciences into HBV cure research to address gaps in treatment acceptance and equity.

## Key findings

- Current HBV cure research lacks attention to treatment discontinuation acceptability and stigma.
- Co-infections like HIV and resource limitations in translation hinder cure development.
- A multidisciplinary framework is needed to ensure equitable and scalable HBV cures.

## Abstract

We examine the current understanding of the multidisciplinary aspects of hepatitis B cure research, such as socio-behavioral sciences, ethics, community engagement, and translational and implementation science.

The peer-reviewed literature on the multi-disciplinary aspects of HBV cure research is gradually expanding, although several areas still require attention. These deficiencies include: the acceptability of HBV treatment discontinuations, HBV-related stigma, the impact of co-infections (e.g., HIV), and the translation of discoveries to resource-limited settings.

This review highlights the importance of a multidisciplinary framework that bridges socio-behavioral sciences, ethics, community engagement, and translational and implementation science to help ensure the development of an effective, acceptable, scalable and equitable HBV cure.