# Concurrent Lupus Nephritis and Lupus Carditis in a Young Woman With Systemic Lupus Erythematosus: A Case Report With an Incidental Arachnoid Cyst

**Authors:** Ahmad Mohammad, Bhavna Singla, Shivam Singla, Sahil Kumar, Arif Tajammul

PMC · DOI: 10.7759/cureus.94138 · Cureus · 2025-10-08

## TL;DR

A young woman with lupus developed kidney and heart complications, and an incidental brain cyst was found during her treatment.

## Contribution

This case report highlights the rare concurrent occurrence of lupus nephritis and carditis in SLE with an incidental arachnoid cyst.

## Key findings

- The patient showed improvement with corticosteroids, cyclophosphamide, and hydroxychloroquine.
- Brain imaging revealed an incidental arachnoid cyst unrelated to SLE.
- The case underscores the importance of multidisciplinary care in managing complex SLE presentations.

## Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with highly variable clinical presentations. We report the case of a 32-year-old woman who presented with fever, polyarthritis, rash, and renal and cardiac involvement. Laboratory and immunological investigations confirmed SLE with Class IV lupus nephritis and lupus carditis, while brain imaging incidentally revealed an arachnoid cyst. The patient received high-dose corticosteroids, cyclophosphamide, and hydroxychloroquine, resulting in marked clinical and laboratory improvement, with the stabilization of renal function and the resolution of cardiac inflammation. This case highlights the importance of early recognition of severe multi-organ involvement in SLE, the application of standardized diagnostic criteria, and the benefits of a multidisciplinary treatment approach. It also emphasizes the need for careful interpretation of incidental findings to avoid misattribution, providing valuable teaching points for clinicians managing complex autoimmune disease presentations.

## Linked entities

- **Chemicals:** cyclophosphamide (PubChem CID 2907), hydroxychloroquine (PubChem CID 3652)
- **Diseases:** Systemic Lupus Erythematosus (MONDO:0007915), lupus nephritis (MONDO:0005556), arachnoid cyst (MONDO:0008813)

## Full-text entities

- **Diseases:** Lupus Carditis (MESH:D009205), SLE (MESH:D008180), polyarthritis (MESH:D001168), Class IV lupus nephritis (MESH:D008181), autoimmune disease (MESH:D001327), Arachnoid Cyst (MESH:D016080), renal and cardiac involvement (MESH:C565423), rash (MESH:D005076), fever (MESH:D005334), cardiac inflammation (MESH:D007249)
- **Chemicals:** hydroxychloroquine (MESH:D006886), cyclophosphamide (MESH:D003520)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12596172/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12596172/full.md

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Source: https://tomesphere.com/paper/PMC12596172