# OncotreeVIS—an interactive graphical user interface for visualizing mutation tree cohorts

## TL;DR

OncotreeVIS is a tool for visualizing and analyzing mutation trees in tumors, helping researchers explore genetic events and drug interactions in cancer cohorts.

## Contribution

OncotreeVIS introduces an interactive GUI for visualizing mutation tree cohorts and posterior distributions, enabling detailed inspection and comparison.

## Key findings

- OncotreeVIS supports visualization of mutation trees with single or joint genetic events.
- The tool highlights subclones, conserved trajectories, and drug-gene interactions at the cohort level.
- It is available as a JavaScript library and web application with default datasets for immediate use.

## Abstract

In recent years, developments in single-cell next-generation sequencing technology and computational methodology have made it possible to reconstruct, with increasing precision, the evolutionary history of tumors and their cell phylogenies, represented as mutation trees. Many mutation tree inference tools exist, but they do not support detailed visual tree inspection, nor tree comparisons or analysis at the cohort level, an important task in computational oncology. We developed oncotreeVIS, an interactive graphical user interface for visualizing mutation tree cohorts and tree posterior distributions obtained from mutation tree inference tools. OncotreeVIS can display mutation trees that encode single or joint genetic events, such as point mutations and copy number changes, and highlight matching subclones, conserved trajectories and drug-gene interactions at the cohort level. OncotreeVIS facilitates the visual inspection of mutation tree clusters and pairwise tree distances. It is available both as a JavaScript library that can be used locally or as a web application that can be accessed online. It includes seven default datasets of public mutation tree cohorts for visualization, while new mutation trees are provided in a predefined JSON format.

https://cbg-ethz.github.io/oncotreeVIS.