# Management of Non-Islet Cell Tumor Hypoglycemia Induced by Adrenal Cortical Carcinoma

## TL;DR

This paper discusses a rare case of hypoglycemia caused by adrenal cancer and highlights the challenges in treating this condition.

## Contribution

The paper presents a rare case of ACC-induced NICTH and highlights the limitations of current medical therapies.

## Key findings

- NICTH caused by adrenal cortical carcinoma is extremely rare.
- Current medical therapies for nonoperable NICTH are limited and often ineffective.
- The case emphasizes the need for improved diagnostic and treatment approaches for NICTH.

## Abstract

Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome that significantly worsens the prognosis of underlying malignancies. It is characterized by hypoglycemia resulting from ectopic production of insulin-like growth factor 2. NICTH caused by adrenal cortical carcinoma (ACC) is extremely rare. To date, no curative treatment of nonoperable NICTH has been reported. In this report, we describe a case of ACC-induced NICTH that was refractory to multiple treatments for hypoglycemia. It provides diagnostic and treatment approaches for NICTH and emphasizes the limitations of existing medical therapies for NICTH.