Theobroma cacao seed extracts attenuate dyslipidemia and oxidative stress in L-NAME induced hypertension in Wistar rats
Eyuwa I. Agwupuye, Abdulhakeem R. Agboola, Yu-Cheng Kuo, Ako H. Itam, Lawrence U. Ezeayinka, Item J. Atangwho, Bolaji M. Ayeyemi, Adeleye A. Edema, Bashir Lawal, Modhi O. Alotaibi, Najlaa Hamed Almohmadi, Gaber El-Saber Batiha, Nasser M. El-Sabbagh, Hsu-Shan Huang
TL;DR
This study shows that Theobroma cacao seed extracts can reduce high blood pressure and oxidative stress in rats, suggesting potential benefits for heart health.
Contribution
The study demonstrates the antihypertensive and antioxidant effects of T. cacao seed extracts in a rat model of hypertension.
Findings
Ethanol and chloroform extracts of T. cacao showed dose-dependent antioxidant activity in vitro.
Extracts significantly reduced harmful lipids and oxidative stress markers in hypertensive rats.
Ethanol extracts outperformed chloroform extracts in antioxidant and lipid-lowering effects.
Abstract
This research evaluated the antioxidant activities (in vitro and in vivo) and serum lipid profile of the chloroform (CETC) and ethanol (EETC) extracts of Theobroma cacao seeds in nitro-L-arginine methyl esters (L-NAME)-induced hypertension in Wister rats. Parameters investigated include DPPH, nitric oxide scavenging ability, CAT, GPX, SOD and serum MDA concentration. Serum lipid profiles such as total cholesterol, HDL, LDL, VLDL and TG were also assayed. The rats were treated with 100mg/kg, 200mg/kg and 300mg/kg b. w of ethanol and chloroform extracts of T. cacao and a standard drug concurrently with L-NAME. The results showed a dose-dependent increase in the antioxidant activities of EETC and CETC across all the invitro parameters with the ethanol extracts consistently outperforming the chloroform extracts. Total cholesterol, low-density lipoproteins, very low-density lipoprotein, TGs,…
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Taxonomy
TopicsFood Chemistry and Fat Analysis · Phytochemicals and Antioxidant Activities · Coconut Research and Applications