Mapping the developmental path for Parkinson’s disease therapeutics
Neel T. Dhruv, Sarah Robinson Schwartz, Christine Swanson-Fischer, Hyun Joo Cho, Rebekah Corlew, Lyn Jakeman, Lauren A. Laboissonniere, Rebecca Price, Shireen Sarraf, Beth-Anne Sieber, Christine Torborg, Carl Wonders, Alice Chen-Plotkin, William J. Martin, Amir P. Tamiz
TL;DR
This paper summarizes a workshop aimed at addressing the gap between Parkinson's disease research and therapeutic development.
Contribution
The paper provides insights and strategies from stakeholder discussions to accelerate PD therapeutics development.
Findings
Workshop participants emphasized PD heterogeneity and the need for better target validation.
Development of tools and biomarkers was identified as critical for advancing therapeutics.
Comparisons with other neurodegenerative diseases highlighted shared and unique challenges.
Abstract
The National Institute of Neurological Disorders and Stroke (NINDS) held an open workshop on April 23 and 24, 2024 to evaluate the gap between the current understanding of Parkinson’s disease (PD) and the development of therapeutics for treating PD. Representatives from key stakeholder groups discussed strategies for leveraging research to bridge this gap. Sessions focused on PD heterogeneity, target validation, development of tools and resources to facilitate therapeutics development, biomarker discovery and use, similarities and differences with PD-adjacent neurodegenerative diseases, and best practices for accelerating the therapeutics development process. Here are some of the main takeaways from the workshop.
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsParkinson's Disease Mechanisms and Treatments · Nuclear Receptors and Signaling · Phosphodiesterase function and regulation