# [Expression of Concern] CDKN2A (p16INK4A) affects the anti-tumor effect of CDK inhibitor in somatotroph adenomas

**Authors:** Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang

PMC · DOI: 10.3892/ijmm.2025.5680 · 2025-10-29

## Full-text entities

- **Genes:** Egfr (epidermal growth factor receptor) [NCBI Gene 24329] {aka ERBB1, ErbB-1, Errp}, Gapdh (glyceraldehyde-3-phosphate dehydrogenase) [NCBI Gene 24383] {aka BARS-38, Gapd}, Cdkn2a (cyclin-dependent kinase inhibitor 2A) [NCBI Gene 25163] {aka Arf, INK4A, MTS1, p16, p16Cdkn2a, p19ARF}
- **Diseases:** tumor (MESH:D009369), somatotroph adenomas (MESH:D049912)
- **Cell lines:** GH3 — Rattus norvegicus (Rat), Rat pituitary gland neoplasm, Cancer cell line (CVCL_0273), GT1-1 — Mus musculus (Mouse), Transformed cell line (CVCL_6236)

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Source: https://tomesphere.com/paper/PMC12594515