# A Rare Case of Cutaneous Meningioma Arising on the Scalp: Diagnostic Challenges, Immunohistochemical, and Molecular Features

**Authors:** Kainat Memon, Richard J Digby, Azzam Ismail

PMC · DOI: 10.7759/cureus.94117 · 2025-10-08

## TL;DR

A rare case of cutaneous meningioma on the scalp highlights the need for combining clinical and lab findings for accurate diagnosis.

## Contribution

This case report emphasizes the diagnostic value of integrating histopathology, immunohistochemistry, and molecular studies for rare scalp tumors.

## Key findings

- A scalp lesion initially thought to be an epidermoid cyst was diagnosed as cutaneous meningioma.
- Combining clinical, histopathological, and molecular data is crucial for diagnosing rare extracranial meningiomas.
- Cutaneous meningioma is a rare condition requiring multidisciplinary diagnostic approaches.

## Abstract

The differential diagnosis for scalp lesions is broad, ranging from simple cysts to tumors. We present the case of a 49-year-old woman with a scalp lesion initially suspected to be an epidermoid cyst but later diagnosed as cutaneous meningioma on biopsy. As a rare form of extracranial meningioma, this case underscores the importance of correlating clinical findings with histopathology, such as integrating morphological features, immunohistochemical markers, and molecular studies, to establish a diagnosis in challenging cases with inconclusive clinical or radiological findings.

## Full-text entities

- **Diseases:** Cutaneous Meningioma (MESH:D008579), cysts (MESH:D003560), scalp lesion (MESH:D004476), epidermoid cyst (MESH:D004814), tumors (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12594048/full.md

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Source: https://tomesphere.com/paper/PMC12594048