# Odontogenic Keratocyst of the Anterior Mandible Mimicking Lateral Periodontal Cyst

**Authors:** Shilpa Mathew, Roshni Ramesh, S. Santhosh Kumar

PMC · DOI: 10.7759/cureus.94112 · 2025-10-08

## TL;DR

A rare case of an odontogenic keratocyst in the front lower jaw was misdiagnosed as a lateral periodontal cyst but confirmed through histopathology.

## Contribution

Highlights the importance of histopathological diagnosis for maxillofacial lesions that appear similar clinically and radiographically.

## Key findings

- A 47-year-old woman's lesion was initially diagnosed as a lateral periodontal cyst but confirmed as OKC via histopathology.
- The OKC was located in a rare anterior mandibular region and showed no recurrence after three years of follow-up.
- Histopathological examination is essential for accurate diagnosis of clinically and radiographically similar jaw lesions.

## Abstract

Odontogenic keratocyst (OKC) is thought to be an odontogenic cyst of developmental origin that can arise at any place in the jaws, but mostly occurs in the mandibular angle and ramus area. It is clinically indistinguishable from a lateral periodontal cyst. A proper diagnosis can only be made based on histopathological examination. A 47-year-old woman presented with a gingival swelling on the inner aspect of the anterior region of the lower jaw. The swelling was of one year's duration and asymptomatic. Intraoral periapical radiograph revealed a well-defined oval radiolucency in the interradicular area of the lower left mandibular incisors. Cone-beam computed tomography revealed destruction of the lingual cortical plate. A provisional diagnosis of lateral periodontal cyst was made. The lesion was enucleated, and the bone defect was filled with advanced platelet-rich fibrin. Histopathological examination confirmed a diagnosis of OKC. Patient follow-up after three years showed no recurrence. By reporting this rare location of OKC, the authors would like to emphasize that there is a vast variety of maxillofacial bone lesions that resemble each other clinically and radiographically, and hence, a histopathological examination should be done for a definitive diagnosis.

## Linked entities

- **Diseases:** odontogenic keratocyst (MONDO:0018648)

## Full-text entities

- **Diseases:** swelling (MESH:D004487), OKC (MESH:D009807), bone defect (MESH:D001847), gingival swelling (MESH:D005891), Lateral Periodontal Cyst (MESH:D010509)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12594044/full.md

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Source: https://tomesphere.com/paper/PMC12594044