# Development of a quantitative job exposure matrix for standing, walking, and forward bending among pregnant workers – The PRECISE JEM

**Authors:** Hannah Nørtoft Frankel, Esben Meulengracht Flachs, Camilla Sandal Sejbaek, Jonathan Aavang Petersen, Jens Peter Bonde, Ingrid Sivesind Mehlum, Mette Korshøj, Susan Peters, Magnus Svartengren, Pasan Hettiarachchi, Peter J Johansson, Alex Burdorf, Luise Mølenberg Begtrup

PMC · DOI: 10.5271/sjweh.4252 · 2025-10-30

## TL;DR

This paper creates a detailed job exposure matrix to assess physical activity levels in pregnant workers, aiming to improve understanding of how occupational activities affect pregnancy outcomes.

## Contribution

The study introduces a trimester-specific job exposure matrix for standing, walking, and forward bending among pregnant workers using objective measurements.

## Key findings

- The JEM estimates exposure levels for 1171 job codes using accelerometer data and mixed-effects models.
- Bakers had the highest standing exposure, while waiters and livestock producers had the highest walking and forward bending exposure, respectively.
- Trimester-specific adjustments showed reduced standing time in the third trimester compared to non-pregnant workers.

## Abstract

Occupational physical activity (OPA) during pregnancy has been linked to adverse pregnancy outcomes, but crude exposure assessment remains an issue in causal inference. We aimed to develop a quantitative trimester-specific job exposure matrix (JEM) for standing, walking, and forward bending among pregnant workers.

Accelerometer measurements from 403 female workers across 109 DISCO-08 job codes were obtained in Denmark between January 2023 and June 2024. Full workdays were measured during two weeks among pregnant workers and one week among non-pregnant workers. We used linear mixed-effects models to estimate exposure levels of occupational standing, walking, and forward bending for all 1171 DISCO-08 codes, including age, trimester, and expert ratings as fixed effects, and job codes and workers as random effects.

The between-job variances relative to total variances were 56% for standing, 51% for walking, and 45% for forward bending. The fixed effect trimester reduced standing time by 0.38 hours during the 3rd trimester compared to non-pregnant participants, whereas no differences were observed for walking or forward bending. Based on the trimester-specific JEM for occupational standing time, bakers had the highest exposure (range from non-pregnant to 3rd trimester, 5.41–5.03 hours/workday). For walking and forward bending, the highest exposed jobs from the pregnancy-specific JEM were waiters (1.76 hours/workday) and livestock/dairy producers (1.24 hours/workday), respectively.

The JEM enhances independent objective exposure assessment in epidemiological studies of OPA and pregnancy outcomes and may advance guidelines and potentially prevent adverse pregnancy outcomes.

## Full-text entities

- **Diseases:** carcinogenic (MESH:D011230), OPA (MESH:D009784), JEM (MESH:D007589), fatigue (MESH:D005221), fetal growth restriction (MESH:D005317), nausea (MESH:D009325), preterm birth (MESH:D047928), miscarriage (MESH:D000022), Weight gain (MESH:D015430)
- **Chemicals:** OPA (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12593706/full.md

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Source: https://tomesphere.com/paper/PMC12593706