# Right ventricular pressure-volume loop analysis in congenital heart disease

**Authors:** Renée S. Joosen, Michael G. Dickinson, Marielle C. van de Veerdonk, Rahi S. Alipour Symakani, Daphne Merkus, Michiel Voskuil, Gregor J. Krings, Johannes M.P.J. Breur

PMC · DOI: 10.1016/j.ijcchd.2025.100625 · International Journal of Cardiology Congenital Heart Disease · 2025-10-02

## TL;DR

This paper explains how right ventricular pressure-volume loop analysis using the multi-beat method can safely assess heart function in patients with congenital heart disease.

## Contribution

The paper introduces a reliable and safe method for RV PV loop analysis in both pediatric and adult CHD patients.

## Key findings

- RV PV loop analysis via the multi-beat method is safe and reliable in complex CHD patients.
- RV PV loops provide advanced insight into RV adaptation to pressure and volume overload in CHD patients.
- Improved understanding of RV adaptation may enhance patient care and optimize treatment strategies.

## Abstract

Right ventricular (RV) function is an independent predictor of prognosis in patients with congenital heart disease (CHD). Early detection is therefore crucial but current methods to assess RV function are highly load-dependent. RV pressure-volume (PV) loop analysis is an invasive technique which is load-independent and considered the gold standard for evaluating RV adaptation in relation to its load. However, RV PV loop analysis can be time consuming and prone to inter-operator variability.

This article provides a comprehensive guide on performing RV PV loop analysis using the multi-beat method in pediatric and adult patients with complex CHD.

RV PV loop analysis using the multi-beat method can be safely and reliably applied in children and adults with complex CHD.

RV PV loop analysis offers a valuable tool for advanced insight into RV adaptation and a deeper understanding of cardiac physiology in complex CHD patients with RV pressure and/or volume overload. By enhancing our understanding of RV adaptation, this approach holds great potential for improving patient management and optimizing treatment strategies.

•RV PV loop analysis via multi-beat method is safe and reliable in complex CHD patients.•RV PV loops give advanced insight into RV adaptation to pressure/volume overload in CHD patients.•Improved insight in RV adaptation may enhance patient care and optimize treatment in CHD.

RV PV loop analysis via multi-beat method is safe and reliable in complex CHD patients.

RV PV loops give advanced insight into RV adaptation to pressure/volume overload in CHD patients.

Improved insight in RV adaptation may enhance patient care and optimize treatment in CHD.

## Linked entities

- **Diseases:** congenital heart disease (MONDO:0005453)

## Full-text entities

- **Diseases:** CHD (MESH:D006330), volume overload (MESH:D019190)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12593703/full.md

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Source: https://tomesphere.com/paper/PMC12593703