# Peer review of the pesticide risk assessment of the active substance phenmedipham

**Authors:** Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, Monica Fittipaldi Broussard, German Giner Santonja, Varvara Gouliarmou, Katrin Halling, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza

PMC · DOI: 10.2903/j.efsa.2025.9711 · EFSA Journal · 2025-11-07

## TL;DR

This paper summarizes the peer review of phenmedipham, a pesticide, assessing its risks and regulatory compliance in the EU.

## Contribution

The paper updates the risk assessment of phenmedipham with new evaluations on endocrine disruption and genotoxicity.

## Key findings

- Phenmedipham's use as a herbicide on sugar beet/fodder beet was evaluated for regulatory compliance.
- New concerns were identified regarding endocrine disrupting properties and genotoxicity.
- Some required information for regulatory compliance is still missing.

## Abstract

The conclusions of EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Finland and co‐rapporteur Member State Denmark for the pesticide active substance phenmedipham are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. The conclusions were reached on the basis of the evaluation of the representative uses of phenmedipham as a herbicide on sugar beet/fodder beet. The conclusions were updated with regard to the endocrine disrupting properties and the genotoxicity assessment following a mandate received from the European Commission in January 2019 and its update in January 2024, respectively. The reliable end points, appropriate for use in regulatory risk assessment, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.

## Linked entities

- **Chemicals:** phenmedipham (PubChem CID 24744)

## Full-text entities

- **Diseases:** endocrine disrupting (MESH:D004700)
- **Chemicals:** phenmedipham (MESH:C100128)
- **Species:** Beta vulgaris subsp. vulgaris (field beet, subspecies) [taxon 3555]

## Full text

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## Figures

12 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12593531/full.md

## References

42 references — full list in the complete paper: https://tomesphere.com/paper/PMC12593531/full.md

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Source: https://tomesphere.com/paper/PMC12593531