# Hair Repigmentation Outcomes in Patients With Graying Hair Treated With Exosome Therapy: A Cross‐Sectional Observational Study

## TL;DR

Exosome therapy may safely restore hair color in gray-haired patients, with better results for those with recent graying and hair loss.

## Contribution

This study provides clinical evidence that exosome therapy can induce hair repigmentation and identifies predictors of treatment success.

## Key findings

- Exosome therapy led to hair repigmentation in 60% of patients with at least 50% improvement.
- Shorter graying duration, presence of androgenetic alopecia, and moderate baseline severity predicted better outcomes.
- No adverse events were reported during the treatment period.

## Abstract

Hair graying is an age‐associated condition primarily caused by the depletion and dysfunction of melanocyte stem cells within hair follicles. Emerging regenerative strategies, including exosome‐based therapies, offer the potential to restore pigmentation by targeting underlying cellular mechanisms.

To investigate the clinical outcomes and correlates of hair repigmentation following exosome‐based therapy in individuals with gray hair.

This cross‐sectional observational study enrolled 10 patients with visible gray or white hair who were treated with rose stem cell‐derived exosomes (RSCEs) using various procedures. Gray hair repigmentation outcomes were assessed using a standardized scale. Statistical correlations between clinical variables and treatment responses were analyzed.

A mean of 4.6 ± 1.3 treatment sessions was performed. Repigmentation was observed after an average of 2.4 ± 0.7 sessions and was maintained for 4.7 ± 1.9 months. The various treatment modalities also demonstrated efficacy in both hair regrowth and hair repigmentation. The mean outcome score was 2.8 ± 0.78, with 60% achieving a higher‐grade response (≥ 50% improvement). Shorter duration of graying (p = 0.0363), presence of androgenetic alopecia (AGA) (p = 0.0332), and moderate baseline severity (Stage 2) (p = 0.0133) were significantly associated with better outcomes. No adverse events were reported.

Exosome‐based therapy appears to be a safe and promising approach for inducing hair repigmentation in individuals with gray hair using various treatment modalities. Factors such as the presence of AGA, shorter duration of graying, and moderate baseline severity may predict a better response. Larger, controlled studies are warranted to validate these findings and help standardize treatment protocols.