# Silent Threat: Multi‐Organ Failure in Neonatal Scrub Typhus Without Traditional Markers

## TL;DR

Newborns with scrub typhus may show multi-organ failure without typical symptoms, but early diagnosis using advanced sequencing can improve outcomes.

## Contribution

Highlights the use of metagenomic next-generation sequencing for rapid and accurate diagnosis of scrub typhus in neonates.

## Key findings

- Scrub typhus in newborns can present with multi-organ failure without traditional clinical markers.
- Metagenomic next-generation sequencing enables rapid and accurate pathogen diagnosis in neonatal cases.

## Abstract

Scrub typhus, an acute zoonotic disease from
Orientia tsutsugamushi
, is uncommon in newborns and presents atypical symptoms. Untimely diagnosis and treatment can lead to a prolonged and potentially fatal course. Early diagnosis and treatment are essential for better patient outcomes. Metagenomic next‐generation sequencing can rapidly and accurately diagnose pathogens, aiding precise treatment.