# p62-dependent caspase-2 activation governs TDP-43 clearance and neuronal fate in ALS

**Authors:** Pavel I. Volik, Gelina S. Kopeina, Boris Zhivotovsky, Alexey V. Zamaraev

PMC · DOI: 10.1038/s41419-025-08118-6 · Cell Death & Disease · 2025-11-06

## Full-text entities

- **Genes:** NUP62 (nucleoporin 62) [NCBI Gene 23636] {aka IBSN, SNDI, p62}, TARDBP (TAR DNA binding protein) [NCBI Gene 23435] {aka ALS10, TDP-43}, CASP2 (caspase 2) [NCBI Gene 835] {aka CASP-2, ICH1, MRT80, NEDD-2, NEDD2, PPP1R57}
- **Diseases:** ALS (MESH:D008113)

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Source: https://tomesphere.com/paper/PMC12592556