# Stiff-Person Syndrome: A Case Report and Treatment Modalities

## TL;DR

A 64-year-old woman with stiff-person syndrome found significant relief from symptoms after receiving Botox injections, suggesting it could be a helpful treatment option.

## Contribution

This case report introduces Botox as a potential adjunctive therapy for managing stiff-person syndrome symptoms.

## Key findings

- The patient experienced marked improvement in rigidity and daily functioning after Botox injections.
- Symptom relief lasted approximately three months per session with no significant adverse effects.
- Botox may serve as a safe and effective treatment for SPS when standard therapies fail.

## Abstract

Stiff-person syndrome (SPS) is a rare autoimmune neurologic disorder characterized by fluctuating muscle rigidity and painful spasms. It is often refractory to standard therapies such as benzodiazepines, baclofen, and intravenous immunoglobulin (IVIG). We present the case of a 64-year-old African American female with SPS who experienced limited relief from opioids, muscle relaxants, IVIG, and a single intrathecal baclofen dose. Following intramuscular onabotulinumtoxinA (Botox) injections, she reported marked improvement in rigidity, posture, gait, and activities of daily living, with relief lasting approximately three months per session and no significant adverse effects. This case highlights the potential role of Botox as a safe and effective adjunctive therapy in the symptomatic management of SPS, warranting further research into its long-term efficacy and integration into treatment strategies for refractory cases.