# Intravenous iron for the treatment of iron deficiency in adults with cystic fibrosis: a prospective observational cohort study

## TL;DR

Intravenous iron treatment improved hemoglobin and exercise capacity in adults with cystic fibrosis and iron deficiency, without causing infection-related issues.

## Contribution

This study demonstrates the safety and efficacy of intravenous iron in treating iron deficiency among cystic fibrosis patients.

## Key findings

- Intravenous iron improved blood hemoglobin concentration in cystic fibrosis patients.
- Exercise capacity increased without adverse effects on infection markers.

## Abstract

Iron deficiency is common in chronic cardiorespiratory disease. In patients with heart failure and iron deficiency, intravenous iron improves exercise capacity and quality of life [1]. Similar benefits have been reported in patients with pulmonary hypertension [2] and COPD [3]. The mechanism remains unclear, but in addition to its importance in erythropoiesis, iron availability influences the hypoxia-inducible factor (HIF) transcriptional pathway and modulates physiological responses to hypoxia, particularly within the pulmonary circulation [4].

In this pilot study in 20 adults with cystic fibrosis and iron deficiency, treatment with intravenous iron improved blood haemoglobin concentration and exercise capacity, without any adverse effect on clinical or laboratory markers of infection
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