# Rhabdomyolysis and Hepatitis Associated with Oropouche Fever: Brazil

**Authors:** Kalyne Gabrielle Caetano Ferreira, João Hugo Abdalla Santos, Geovana Ribeiro Pinheiro, Ligia Fernandes Abdalla, Lucas Carneiro dos Santos

PMC · DOI: 10.4269/ajtmh.25-0107 · The American Journal of Tropical Medicine and Hygiene · 2025-08-14

## TL;DR

A rare case of rhabdomyolysis and hepatitis caused by Oropouche virus in Brazil is reported, showing the virus's potential severity and the patient's recovery with basic treatment.

## Contribution

This is the first reported case of rhabdomyolysis associated with Oropouche fever in Brazil.

## Key findings

- Rhabdomyolysis was confirmed in a patient infected with Orthobunyavirus oropoucheense.
- The patient also showed neutropenia, thrombocytopenia, and hepatitis.
- The patient recovered well with only analgesia and intravenous hydration.

## Abstract

This study presents a rare case of rhabdomyolysis caused by Orthobunyavirus oropoucheense in a 21-year-old male patient in the Amazon region. The diagnosis was confirmed by the reverse transcription polymerase chain reaction test. Neutropenia, thrombocytopenia, and hepatitis were also identified by laboratory tests, demonstrating the clinical relevance as they are alterations with potential severity. The patient’s good recovery is noteworthy, with only simple analgesia and intravenous hydration. The case highlights the need for better clarification regarding the pathophysiology of this distinct arbovirus.

## Linked entities

- **Diseases:** rhabdomyolysis (MONDO:0005290), hepatitis (MONDO:0002251), Oropouche fever (MONDO:0000345)
- **Species:** Orthobunyavirus oropoucheense (taxon 3052429)

## Full-text entities

- **Diseases:** Neutropenia (MESH:D009503), Hepatitis (MESH:D056486), thrombocytopenia (MESH:D013921), Rhabdomyolysis (MESH:D012206), Oropouche Fever (MESH:D002044)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12590969/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12590969/full.md

## References

24 references — full list in the complete paper: https://tomesphere.com/paper/PMC12590969/full.md

---
Source: https://tomesphere.com/paper/PMC12590969