# Thunderclap headache as an initial manifestation of acute aortic dissection: a case report and review of literature

**Authors:** Mario Ranjeevan, Valeriia Nielsen, Egon Stenager, Sepehr Mamoei

PMC · DOI: 10.3389/fcvm.2025.1598757 · Frontiers in Cardiovascular Medicine · 2025-10-23

## TL;DR

A 54-year-old man presented with a severe headache and neurological symptoms, which were later found to be caused by an acute aortic dissection.

## Contribution

This case report highlights thunderclap headache as a rare initial sign of aortic dissection and emphasizes the importance of early diagnosis.

## Key findings

- Thunderclap headache can be an initial manifestation of acute aortic dissection.
- CT angiography is crucial for timely diagnosis and treatment of aortic dissection.
- Symptoms like headache and neurological deficits should raise suspicion for aortic dissection.

## Abstract

The authors describe the case of a 54-year-old man with sudden onset severe headache accompanied by transitory sensory-motor deficits in all extremities, and mild abdominal pain as the initial manifestation of acute aortic dissection. Despite clinical symptoms mimicking subarachnoid hemorrhage and transitory cerebral ischemia, CT-angiography of the cerebrum and thorax revealed a Stanford type A aortic dissection. Consequently, the patient underwent insertion of a prosthesis at the aortic root and arch. In this case report, we suggest a high level of suspicion for aortic dissection in patients presenting with a sudden severe headache and/or neurological deficits accompanied by chest/back/abdominal pain, nausea, and loss of consciousness. At the same time, asymmetry of pulse and blood pressure asymmetry of the arms should also raise suspicion. An acute CT angiography with the aim of timely diagnosis will allow earlier treatment for this life-threatening condition.

## Linked entities

- **Diseases:** subarachnoid hemorrhage (MONDO:0005099)

## Full-text entities

- **Diseases:** asymmetry of pulse and blood pressure asymmetry (MESH:D005146), loss of consciousness (MESH:D014474), subarachnoid hemorrhage (MESH:D013345), neurological deficits (MESH:D009461), sensory-motor deficits (MESH:D001289), nausea (MESH:D009325), cerebral ischemia (MESH:D002545), headache (MESH:D006261), abdominal pain (MESH:D015746), Stanford type A aortic dissection (MESH:D000784)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

29 references — full list in the complete paper: https://tomesphere.com/paper/PMC12590501/full.md

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Source: https://tomesphere.com/paper/PMC12590501