# Invasive Mole of the Uterus: A Case Report

**Authors:** Alicja Dorota, Piotr Ficenes, Nicole Maryniak, Michal Dorota, Bartosz Czyzewski

PMC · DOI: 10.7759/cureus.94005 · Cureus · 2025-10-07

## TL;DR

A 31-year-old woman with an invasive hydatidiform mole in the uterus was successfully treated with a supracervical hysterectomy after other methods failed.

## Contribution

This case report highlights the effectiveness of supracervical hysterectomy for invasive mole when fertility preservation is not required.

## Key findings

- Fractional curettage, hysteroscopy, and laparoscopy were ineffective in treating the invasive mole.
- Supracervical hysterectomy successfully reduced hCG levels to <1.2 mIU/ml.
- Histopathological examination confirmed the diagnosis of invasive hydatidiform mole.

## Abstract

This case presents a 31-year-old patient who was admitted due to secondary amenorrhea and high beta-human chorionic gonadotropin (hCG) levels. During hospitalization, a hydatidiform mole was identified. Initially, fractional curettage, hysteroscopy, and laparoscopy were performed. Due to the ineffectiveness of these methods, it was decided to perform a supracervical hysterectomy. Histopathological examination confirmed the presence of an invasive hydatidiform mole. hCG levels were monitored until they dropped to <1.2 mIU/ml. This case shows that surgical treatment can be an effective method for the patient if preservation of fertility is not necessary.

## Linked entities

- **Proteins:** CGA (glycoprotein hormones, alpha polypeptide)
- **Diseases:** hydatidiform mole (MONDO:0006248), invasive hydatidiform mole (MONDO:0020549)

## Full-text entities

- **Genes:** CGB5 (chorionic gonadotropin subunit beta 5) [NCBI Gene 93659] {aka CGB, HCG}
- **Diseases:** hydatidiform mole (MESH:D006828), secondary amenorrhea (MESH:D000568)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12590186/full.md

## References

16 references — full list in the complete paper: https://tomesphere.com/paper/PMC12590186/full.md

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Source: https://tomesphere.com/paper/PMC12590186